Human milk oligosaccharide profiles and allergic disease up to 18 years

Background Human milk oligosaccharides (HMO) are a diverse range of sugars secreted in breast that have direct and indirect effects on immunity. The profiles HMOs produced differ between mothers. Objective We sought to determine the relationship maternal HMO offspring allergic diseases up age 18 years. Methods Colostrum early lactation samples were collected from 285 mothers enrolled high-allergy-risk birth cohort, Melbourne Atopy Cohort Study. Nineteen measured. Profiles/patterns determined using LCA. Details disease outcomes including sensitization, wheeze, asthma, eczema at multiple follow-ups Adjusted logistic regression analyses generalized estimating equations used allergy. Results levels several highly correlated with each other. LCA 7 distinct memberships 10% 20%. Compared exposed neutral Lewis profile, exposure acidic was associated higher risk asthma over childhood (odds ratio years, 5.82; 95% CI, 1.59-21.23), whereas acidic-predominant profile reduced food sensitization (OR 12 0.08; 0.01-0.67). Conclusions In this some increased decreased risks childhood. Further studies needed confirm these findings realize potential for intervention.